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Thesis

The role of BMP signalling in HSC ontogeny

Abstract:

The haematopoietic stem cell (HSC) is found in the adult human bone marrow, where it gives rise to all the circulating blood cells throughout adulthood. Understanding the signalling events that programme these cells during development will improve HSC in vitro culture, their generation from embryonic stem cells or induced pluripotent stem cells, and their potential therapeutic application. HSCs bud from the floor of the dorsal aorta and seed the bone marrow via circulation. The pr...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Oxford college:
Brasenose College
Role:
Author

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Role:
Supervisor
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Funding agency for:
Meiklejohn, S
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:305597a8-b8cb-42ff-88fd-34b3dd5bf39b
Local pid:
ora:8522
Deposit date:
2014-06-05

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