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The effects of synaptic noise on measurements of evoked excitatory postsynaptic response amplitudes

Abstract:

Spontaneously occurring synaptic events (synaptic noise) recorded intracellularly are usually assumed to be independent of evoked postsynaptic responses and to contaminate measures of postsynaptic response amplitude in a roughly Gaussian manner. Here we derive analytically the expected noise distribution for excitatory synaptic noise and investigate its effects on amplitude histograms. We propose that some fraction of this excitatory noise is initiated at the same release sites that contribut...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/S0006-3495(97)78061-5

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author

Contributors

Wellcome Trust More from this funder
Natural Sciences and Engineering Research Council of Canada More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Biophysical Journal Journal website
Volume:
73
Issue:
1
Pages:
205–219
Publication date:
1997-07-01
DOI:
ISSN:
0006-3495
Language:
English
Subjects:
UUID:
uuid:307138e0-b94a-425a-bb43-fd40c993a175
Local pid:
ora:8114
Deposit date:
2014-02-26

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