Prevention of mother-to-child transmission of hepatitis B virus: protocol for a one-arm, open-label intervention study to estimate the optimal timing of tenofovir in pregnancy
Hepatitis B virus (HBV) remains a public health threat and the main route of transmission is from mother to child (MTCT). Tenofovir disoproxil fumarate (TDF) treatment can reduce MTCT of HBV although the optimal timing to attain undetectable HBV DNA concentrations at delivery is unknown. This protocol describes the procedures following early initiation of maternal TDF prior to 20 weeks gestation to determine efficacy, safety and feasibility of this approach in a limited-resou...
- Publication status:
- Peer review status:
- Peer reviewed
(Version of record, 864.5KB)
- Publisher copy:
- Copyright holder:
- Bierhoff et al.
- Copyright date:
- Rights statement:
- ©2020 Author(s) (or their employer(s)). Re-use permitted under CC BY. Published by BMJ.
- This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record