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Prevention of mother-to-child transmission of hepatitis B virus: protocol for a one-arm, open-label intervention study to estimate the optimal timing of tenofovir in pregnancy

Abstract:

INTRODUCTION:
Hepatitis B virus (HBV) remains a public health threat and the main route of transmission is from mother to child (MTCT). Tenofovir disoproxil fumarate (TDF) treatment can reduce MTCT of HBV although the optimal timing to attain undetectable HBV DNA concentrations at delivery is unknown. This protocol describes the procedures following early initiation of maternal TDF prior to 20 weeks gestation to determine efficacy, safety and feasibility of this approach in a limited-resou...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/bmjopen-2020-038123

Authors


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Role:
Author
ORCID:
0000-0003-2585-1066
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Thrasher Research Fund More from this funder
John Fell Fund More from this funder
Publisher:
BMJ Publishing Group Publisher's website
Journal:
BMJ Open Journal website
Volume:
10
Issue:
9
Article number:
e038123
Publication date:
2020-09-13
Acceptance date:
2020-06-30
DOI:
EISSN:
2044-6055
Pmid:
32928858
Language:
English
Keywords:
Pubs id:
1132671
Local pid:
pubs:1132671
Deposit date:
2020-09-22

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