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Journal article

Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling

Abstract:

The Hedgehog (HH) signalling pathway is a cell–cell communication system that controls the patterning of multiple tissues during embryogenesis in metazoans. In adults, HH signals regulate tissue stem cells and regenerative responses. Abnormal signalling can cause birth defects and cancer. The HH signal is received on target cells by Patched (PTCH1), the receptor for HH ligands, and then transmitted across the plasma membrane by Smoothened (SMO). Recent structural and biochemical studies have ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.sbi.2019.05.015

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Institution:
University of Oxford
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Oxford college:
St Cross College
Role:
Author
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Funding agency for:
Siebold, C
Grant:
647278
More from this funder
Funding agency for:
Kowatsch, C
Grant:
C20724/A16135
More from this funder
Funding agency for:
Siebold, C
Grant:
647278
More from this funder
Funding agency for:
Woolley, R
Grant:
203726/Z/16/Z
Publisher:
Elsevier Publisher's website
Journal:
Current Opinion in Structural Biology Journal website
Volume:
57
Pages:
204-214
Publication date:
2019-06-24
Acceptance date:
2019-05-18
DOI:
EISSN:
1879-033X
ISSN:
0959-440X
Pmid:
31247512
Source identifiers:
1024454
Language:
English
Pubs id:
pubs:1024454
UUID:
uuid:30b51480-9d58-4e23-afab-d8b69f38d347
Local pid:
pubs:1024454
Deposit date:
2019-07-26

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