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Thesis

Variable domain orientations in antigen receptors

Abstract:

Specific recognition of pathogenic molecules by the immune system is mediated by proteins known as antigen receptors. One such component is the antibody. Binding properties of natural and engineered antibodies can be understood by studying the structure of their variable domains, VH and VL. In this thesis we investigate how the two variable domains orientate with respect to one another and therefore influence the geometry of the antigen binding site which is formed between them.

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Institution:
University of Oxford
Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Research group:
Oxford Protein Informatics Group
Oxford college:
Linacre College
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:30c18b4d-18a2-4f0d-895f-35cc24880955
Local pid:
ora:12037
Deposit date:
2015-07-30

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