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Excitation and inhibition in anterior cingulate predict use of past experiences

Abstract:

Dorsal anterior cingulate cortex (dACC) mediates updating and maintenance of cognitive models of the world used to drive adaptive reward-guided behavior. We investigated the neurochemical underpinnings of this process. We used magnetic resonance spectroscopy in humans, to measure levels of glutamate and GABA in dACC. We examined their relationship to neural signals in dACC, measured with fMRI, and cognitive task performance. Both inhibitory and excitatory neurotransmitters in dACC were predic...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.20365

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Institution:
University of Oxford
Oxford college:
Christ Church
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
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Grant:
092759/Z/10/Z
089280/Z/09/Z
WT100973AIA
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Grant:
Stipendary Junior Research Fellowship to NK
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
6
Publication date:
2017-01-05
Acceptance date:
2016-11-29
DOI:
ISSN:
2050-084X
Source identifiers:
668371
Keywords:
Pubs id:
pubs:668371
UUID:
uuid:3114a25a-3531-409c-a3a3-a10bc504f36f
Local pid:
pubs:668371
Deposit date:
2017-01-06

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