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Analysis of iron and iron-interacting protein dynamics during T-cell activation

Abstract:

Recent findings have shown that iron is a powerful regulator of immune responses, which is of broad importance because iron deficiency is highly prevalent worldwide. However, the underlying reasons of why iron is needed by lymphocytes remain unclear. Using a combination of mathematical modelling, bioinformatic analysis and experimental work, we studied how iron influences T-cells. We identified iron-interacting proteins in CD4+ and CD8+ T-cell proteomes that were differentially expressed duri...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2021.714613

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
ORCID:
0000-0001-5977-6602
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
12
Article number:
714613
Publication date:
2021-08-12
Acceptance date:
2021-07-06
DOI:
EISSN:
1664-3224
Language:
English
Keywords:
Pubs id:
1196585
Local pid:
pubs:1196585
Deposit date:
2021-10-25

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