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Thesis

Investigating the control of striatal dopamine neurotransmission by axonal calcium channels and by striatal neuromodulators: Insights for Parkinson's disease

Abstract:

Dopamine (DA) is a key striatal neuromodulator which is central to processes including action selection and reward-related learning. DA dysfunction is associated with a number of psychomotor disorders, most notably of which is Parkinson's disease (PD). This thesis uses fast-scan cyclic voltammetry in acute mouse striatal slices to detect DA release at carbon fibre microelectrodes with subsecond temporal resolution, to investigate factors affecting the presynaptic control of DA release.

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Institution:
University of Oxford
Division:
MSD
Research group:
Cragg
Oxford college:
Pembroke College
Role:
Author

Contributors

Division:
MSD
Role:
Supervisor
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Funding agency for:
Brimblecombe, K
Grant:
Grant H-1003
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:31384235-dbbc-4055-8e3b-a1d292b376d5
Deposit date:
2016-11-15

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