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Target search mode of a disordered transcription factor

Abstract:

Protein disorder is prevalent in proteins which are involved in DNA binding, such as transcription factors. Transcription factors commonly contain disorder within protein-protein interaction interfaces, however a small number of families contain disorder in their DNA binding domain such as the basic leucine zipper proteins (bZIP). bZIP proteins like cAMP response element binding protein (CREB) have a wide range of roles in human health, however the role of disorder in how bZIP proteins find t...

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Division:
MSD
Department:
Biochemistry
Role:
Author

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Role:
Supervisor
ORCID:
0000-0001-7297-7708
Role:
Supervisor
Role:
Supervisor
ORCID:
0000-0003-4489-140X
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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