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Journal article

Immunogenicity and efficacy of Zika virus envelope domain III in DNA, protein, and ChAdOx1 adenoviral-vectored vaccines

Abstract:

The flavivirus envelope protein domain III (EDIII) was an effective immunogen against dengue virus (DENV) and other related flaviviruses. Whether this can be applied to the Zika virus (ZIKV) vaccinology remains an open question. Here, we tested the efficacy of ZIKV-EDIII against ZIKV infection, using several vaccine platforms that present the antigen in various ways. We provide data demonstrating that mice vaccinated with a ZIKV-EDIII as DNA or protein-based vaccines failed to raise fully neu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3390/vaccines8020307

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Role:
Author
ORCID:
0000-0001-7932-2341
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Role:
Author
ORCID:
0000-0002-2736-8740
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Publisher:
MDPI Publisher's website
Journal:
Vaccines Journal website
Volume:
8
Issue:
2
Pages:
307
Publication date:
2020-06-16
Acceptance date:
2020-06-11
DOI:
EISSN:
2076-393X
ISSN:
2076-393X
Pmid:
32560145
Language:
English
Keywords:
Pubs id:
1113855
Local pid:
pubs:1113855
Deposit date:
2020-06-25

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