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Journal article

Regulation of GATA-2 phosphorylation by mitogen-activated protein kinase and interleukin-3

Abstract:

GATA-2 is a member of a family of transcription factors which bind a common DNA sequence motif (WGA-TAR) through an evolutionarily conserved zinc finger domain. An essential role for GATA-2 in the development of hematopoietic stem cells has recently been shown in gene targeting experiments in mice. Here we show that GATA-2 exists in hematopoietic progenitor cells as a phosphoprotein. Stimulation of progenitors with interleukin-3 (IL-3) results in enhanced phosphorylation of GATA-2 which occur...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1074/jbc.270.8.4101

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Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Volume:
270
Issue:
8
Pages:
4101-4107
Publication date:
1995-02-24
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
223744
Language:
English
Keywords:
Pubs id:
pubs:223744
UUID:
uuid:32487bbe-92e8-493a-929b-06c4b7f80124
Local pid:
pubs:223744
Deposit date:
2012-12-19

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