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Journal article

Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium

Abstract:

BACKGROUND: Delirium is a profound neuropsychiatric disturbance precipitated by acute illness. Although dementia is the major risk factor this has typically been considered a binary quantity (i.e., cognitively impaired versus cognitively normal) with respect to delirium risk. We used humans and mice to address the hypothesis that the severity of underlying neurodegenerative changes and/or cognitive impairment progressively alters delirium risk. METHODS: Humans in a population-based longitudin...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jagp.2014.08.005

Authors


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Biotechnology and Biological Sciences Research Council More from this funder
Wellcome Trust More from this funder
Engineering and Physical Sciences Research Council More from this funder
Economic and Social Research Council More from this funder
Medical Research Council More from this funder
Publisher:
Elsevier Publisher's website
Journal:
American Journal of Geriatric Psychiatry Journal website
Volume:
23
Issue:
4
Pages:
403–415
Publication date:
2014-08-01
DOI:
EISSN:
1545-7214
ISSN:
1064-7481
Source identifiers:
485350
Language:
English
Keywords:
UUID:
uuid:32d098e7-d9b0-4f38-a15e-76935b7b9e1f
Local pid:
pubs:485350
Deposit date:
2014-10-01

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