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Thesis

Synthesis of eleutherobin-like potential microtubule stabilising agents

Abstract:

This thesis describes synthetic studies towards the tricyclic terpene framework of the cytotoxic natural product eleutherobin, and the investigation of biocatalytic methodology towards late stage functionalisation of the structure.

Chapter 1 provides an introduction to the biomedical significance of the natural product and to the various synthetic studies reported to date.

Chapter 2 explores intramolecular Diels–Alder approaches to the construction of the nine- and six- membe...

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Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Department:
Chemistry
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:331f563e-efaf-453f-9920-9ae154048f72
Deposit date:
2018-02-19

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