Synthesis of eleutherobin-like potential microtubule stabilising agents
This thesis describes synthetic studies towards the tricyclic terpene framework of the cytotoxic natural product eleutherobin, and the investigation of biocatalytic methodology towards late stage functionalisation of the structure.
Chapter 1 provides an introduction to the biomedical significance of the natural product and to the various synthetic studies reported to date.
Chapter 2 explores intramolecular Diels–Alder approaches to the construction of the nine- and six- membe...Expand abstract
- Type of award:
- Level of award:
- Awarding institution:
- University of Oxford
- Copyright holder:
- Syntrivanis, LD
- Copyright date:
If you are the owner of this record, you can report an update to it here: Report update to this record