Journal article icon

Journal article

Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies

Abstract:

Adenovirus is a widely used vector for cancer gene therapy because of its high infection efficiency and capacity for transgene expression in both dividing and nondividing cells. However, neutralisation of adenovirus by pre-existing antibodies can lead to inefficient delivery, and the wide tissue distribution of the coxsackie and adenovirus receptor (CAR, the primary receptor for adenovirus type 5) precludes target selectivity. These limitations have largely rest...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1038/sj.gt.3301389

Authors


Expand authors...
Publisher:
Springer Nature Publisher's website
Journal:
Gene Therapy Journal website
Publication date:
2001-04-18
Acceptance date:
2000-11-22
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
Source identifiers:
709387
Keywords:
Pubs id:
pubs:709387
UUID:
uuid:3325fc7b-72b7-4e5f-bb8f-9d77f56999e6
Local pid:
pubs:709387
Deposit date:
2017-07-27

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP