Journal article
HIV-1 down-regulates the expression of CD1d via Nef.
- Abstract:
-
HIV-1 has evolved several strategies to subvert host immune responses to the infected cells. One is to inhibit CTL recognition by HIV-1 Nef-mediated down-regulation of MHC-I expression on the surface of infected cells. Here we report that Nef also reduces the expression of the non-classical MHC-I like CD1d molecule, a third lineage of antigen-presenting molecule, which presents lipid antigens. Nef achieves this by increasing internalization of CD1d molecules from the cell surface and retainin...
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- Publication status:
- Published
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- Publisher copy:
- 10.1002/eji.200535487
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Authors
Bibliographic Details
- Journal:
- European journal of immunology
- Volume:
- 36
- Issue:
- 2
- Pages:
- 278-286
- Publication date:
- 2006-02-01
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- Source identifiers:
-
33346
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:33346
- UUID:
-
uuid:3343c82d-4005-43a8-a537-013087bd7d09
- Local pid:
- pubs:33346
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2006
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