Journal article
Engineering cytochrome-modified silica nanoparticles to induce programmed cell death
- Abstract:
-
A low native membrane permeability and ineffective access to the cellular cytosol, together with aggressive proteolytic degradation, often severely hampers the practical application of any therapeutic protein or antibody. Through engineering the charging profile of mesoporous silica nanoparticles, cellular uptake and subsequent subcellular distribution can be controlled. We show herein that programmed cell death can subsequently be induced across a population of cancer cells with remarkable e...
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- Publisher copy:
- 10.1002/chem.201303239
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Authors
Bibliographic Details
- Journal:
- Chemistry - A European Journal
- Volume:
- 19
- Issue:
- 52
- Pages:
- 17891-17898
- Publication date:
- 2013-12-23
- DOI:
- EISSN:
-
1521-3765
- ISSN:
-
0947-6539
- Source identifiers:
-
446033
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:446033
- UUID:
-
uuid:33485b3f-85bd-4aea-beca-13fa164181c3
- Local pid:
- pubs:446033
- Deposit date:
- 2014-02-08
Terms of use
- Copyright date:
- 2013
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