Dataset icon

Dataset

Human DNA Cross-Link Repair 1A (DCLRE1A, SNM1A); A Target Enabling Package

Actions


Access Document


Files:

Authors/Creators


More by this author/creator
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher, Creator

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Principal Investigator (PI)
Institution:
University of Oxford
Oxford college:
Balliol College
Role:
Researcher
Role:
Researcher
Department:
Oncology
Role:
Researcher
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Researcher
Publisher:
University of Oxford
Publication date:
2018
Keywords:
Subjects:
Documentation:
A description of the materials and methods is included within the TEP datasheet. Cancer cells experience genomic instability, probably through a combination of excessive replicative activity and the loss of function of checkpoint and DNA repair pathways that may have contributed to the oncogenic transformation. Chemotherapy by DNA-damaging agents such as cisplatin and nitrogen mustards create DNA interstrand crosslinks (ICL), which can lead to double-strand breaks and cell death when the cell... Expand documentation
UUID:
uuid:334f0870-2042-44ad-b004-eab8dca8d09e
Deposit date:
2018-04-20

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP