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Thesis

Tryptophan catabolism and amino acid transporter reprogramming in the tumour microenvironment

Abstract:

A large proportion of human tumours exploit tryptophan catabolism as a means to suppress T cell activity in the tumour microenvironment. However, the mechanisms that allow tumour cells to resist the detrimental effects of local tryptophan depletion have so far remained obscure. Here we demonstrate that shortage of tryptophan induced by the expression of tryptophan-degrading enzymes indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) results in ATF4-dependent reprogrammin...

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Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Department:
Molecular Medicine
Role:
Author

Contributors

Role:
Supervisor
Cancer Research UK More from this funder
Medical Research Council More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:33745777-7aab-4342-b997-fc4317ec34fb
Deposit date:
2017-02-16

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