Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction.
Diabetes, obesity and Alzheimer’s disease (AD) are associated with vascular complications and impaired nitric oxide (NO) production. Furthermore, increased β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1), APP and β-amyloid (Aβ) are linked with vascular disease development and raised BACE1 and Aβ accompany hyperglycemia and hyperlipidemia. However, the causal relationship between obesity and diabetes, raised Aβ and vascular dysfunction is unclear. We report that diet-induced o...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Copyright holder:
- Meakin et al.
- Copyright date:
- Rights statement:
- © 2020 Meakin et al. This work is licensed under the Creative Commons Attribution 4.0 International License.
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record