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Journal article

Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction.

Abstract:

Diabetes, obesity and Alzheimer’s disease (AD) are associated with vascular complications and impaired nitric oxide (NO) production. Furthermore, increased β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1), APP and β-amyloid (Aβ) are linked with vascular disease development and raised BACE1 and Aβ accompany hyperglycemia and hyperlipidemia. However, the causal relationship between obesity and diabetes, raised Aβ and vascular dysfunction is unclear. We report that diet-induced o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/jci122237

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
Journal of Clinical Investigation Journal website
Volume:
130
Issue:
8
Pages:
4104-4117
Publication date:
2020-05-14
Acceptance date:
2020-04-29
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Pmid:
32407295
Language:
English
Keywords:
Pubs id:
1105125
Local pid:
pubs:1105125
Deposit date:
2020-05-19

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