Journal article
Diverse mechanisms of IRF5 action in inflammatory responses
- Abstract:
-
Interferon regulatory factor 5 (IRF5) is a key signal-dependent transcription factor in myeloid cells. Its expression is induced by granulocyte-macrophage colony stimulating factor and interferon-gamma. IRF5 protein is further activated in response to stimulation, translocating to the nucleus where it mediates inflammatory responses. IRF5 is capable of both the up-regulation of pro-inflammatory genes and repressing anti-inflammatory mediators, thus polarising macrophages to a pro-inflammatory...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ Kennedy Institute Trustees’ Research Fund
More from this funder
Funding agency for:
Khoyratty, T
Udalova, I
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- International Journal of Biochemistry and Cell Biology Journal website
- Volume:
- 99
- Pages:
- 38-42
- Publication date:
- 2018-03-22
- Acceptance date:
- 2018-03-16
- DOI:
- EISSN:
-
1878-5875
- ISSN:
-
1357-2725
- Pmid:
-
29578052
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:833745
- UUID:
-
uuid:33d6055a-f22b-4fe9-a678-562ce0fc982d
- Local pid:
- pubs:833745
- Source identifiers:
-
833745
- Deposit date:
- 2018-09-17
Terms of use
- Copyright date:
- 2018
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