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Thesis

Exploiting pre-existing viral immunity for B cell vaccination against endogenous antigens

Abstract:

Cancer vaccines are a novel method of treating cancer by harnessing the patient’s own immune system to recognise and attack malignant cells. Viral vectors can be used to encode tumour antigens to be presented to the immune system. However this field is hindered by immunity to the viral vectors themselves, which are often more immunogenic than tumour antigens.

This thesis describes the production of a novel cancer vaccine based on murine leukaemia retrovirus (MLV), where the enveloped...

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Oxford college:
Linacre College
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:3403fd5e-a4b2-4691-ab76-0441707c1e83
Deposit date:
2016-11-15

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