Journal article icon

Journal article

H3K79me2/3 controls enhancer–promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells

Abstract:

MLL gene rearrangements (MLLr) are a common cause of aggressive, incurable acute lymphoblastic leukemias (ALL) in infants and children, most of which originate in utero. The most common MLLr produces an MLL-AF4 fusion protein. MLL-AF4 promotes leukemogenesis by activating key target genes, mainly through recruitment of DOT1L and increased histone H3 lysine-79 methylation (H3K79me2/3). One key MLL-AF4 target gene is PROM1, which encodes CD133 (Prominin-1). CD133 is a pentaspan transmembrane gl...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s41375-020-0808-y

Authors


More by this author
Role:
Author
ORCID:
0000-0002-6222-3563
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
ORCID:
0000-0001-9610-6763
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
ORCID:
0000-0002-3116-1646
More by this author
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
ORCID:
0000-0003-1727-3243
More by this author
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
ORCID:
0000-0001-7166-4902
Expand authors...
John Fell Fund More from this funder
Gold September More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Leukemia Journal website
Volume:
35
Issue:
1
Pages:
90–106
Publication date:
2020-04-02
Acceptance date:
2020-03-18
DOI:
EISSN:
1476-5551
ISSN:
0887-6924
Language:
English
Keywords:
Subjects:
Pubs id:
1097651
Local pid:
pubs:1097651
Deposit date:
2020-04-02

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP