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Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response - a predictive kinetic model

Abstract:

Background: The activity of the heterodimeric transcription factor hypoxia inducible factor (HIF) is regulated by the post-translational, oxygen-dependent hydroxylation of its α-subunit by members of the prolyl hydroxylase domain (PHD or EGLN)-family and by factor inhibiting HIF (FIH). PHD-dependent hydroxylation targets HIFα for rapid proteasomal degradation; FIH-catalysed asparaginyl-hydroxylation of the C-terminal transactivation domain (CAD) of HIFα suppresses the CAD-dependent subset...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1752-0509-4-139

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemistry Research Laboratory
Role:
Author
European Union More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
BioMed Cental Ltd. Publisher's website
Journal:
BMC Systems Biology Journal website
Volume:
4
Article number:
139
Publication date:
2010-10-01
DOI:
ISSN:
1752-0509
Language:
English
Subjects:
UUID:
uuid:345439ad-6326-42cb-be30-9d315501881a
Local pid:
ora:5685
Deposit date:
2011-09-09

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