Journal article
A single-cell molecular map of mouse gastrulation and early organogenesis
- Abstract:
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Across the animal kingdom, gastrulation represents a key developmental event during which embryonic pluripotent cells diversify into lineage-specific precursors that will generate the adult organism. Here we report the transcriptional profiles of 116,312 single cells from mouse embryos collected at nine sequential time points ranging from 6.5 to 8.5 days post-fertilization. We construct a molecular map of cellular differentiation from pluripotency towards all major embryonic lineages, and exp...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, zip, 122.0MB)
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- Publisher copy:
- 10.1038/s41586-019-0933-9
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Authors
Funding
+ Biotechnology and Biological Sciences Research Council
More from this funder
Grant:
BBS/E/B/000C0422
+ Biotechnology and Biological Sciences Research Council
More from this funder
Grant:
BBS/E/B/000C0421
Bibliographic Details
- Publisher:
- Nature Research Publisher's website
- Journal:
- Nature Journal website
- Volume:
- 566
- Issue:
- 7745
- Pages:
- 490-495
- Publication date:
- 2019-02-20
- Acceptance date:
- 2018-12-20
- DOI:
- EISSN:
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1476-4687
- ISSN:
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0028-0836
- Pmid:
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30787436
- Source identifiers:
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976305
Item Description
- Language:
- English
- Subjects:
- Pubs id:
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pubs:976305
- UUID:
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uuid:34622b55-8d4f-4c75-9d5a-6223115fe096
- Local pid:
- pubs:976305
- Deposit date:
- 2019-03-13
Terms of use
- Copyright holder:
- Pijuan-Sala, B et al
- Copyright date:
- 2019
- Notes:
- © 2019 Pijuan-Sala, B et al. This is the accepted manuscript version of the article. The final version is available online from Nature Research at: https://doi.org/10.1038/s41586-019-0933-9
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