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A single-cell molecular map of mouse gastrulation and early organogenesis

Abstract:

Across the animal kingdom, gastrulation represents a key developmental event during which embryonic pluripotent cells diversify into lineage-specific precursors that will generate the adult organism. Here we report the transcriptional profiles of 116,312 single cells from mouse embryos collected at nine sequential time points ranging from 6.5 to 8.5 days post-fertilization. We construct a molecular map of cellular differentiation from pluripotency towards all major embryonic lineages, and exp...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41586-019-0933-9

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Role:
Author
ORCID:
0000-0002-2010-2296
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Publisher:
Nature Research Publisher's website
Journal:
Nature Journal website
Volume:
566
Issue:
7745
Pages:
490-495
Publication date:
2019-02-20
Acceptance date:
2018-12-20
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pmid:
30787436
Source identifiers:
976305
Language:
English
Subjects:
Pubs id:
pubs:976305
UUID:
uuid:34622b55-8d4f-4c75-9d5a-6223115fe096
Local pid:
pubs:976305
Deposit date:
2019-03-13

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