Journal article icon

Journal article

Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors

Abstract:

microRNAs are key regulators of the human transcriptome across a number of diverse biological processes, such as development, aging and cancer, where particular miRNAs have been identified as tumour suppressive and oncogenic. In this work, we elucidate, in a comprehensive manner, across 15 epithelial cancer types comprising 7316 clinical samples from the Cancer Genome Atlas, the association of miRNA expression and target regulation with the phenotypic hallmarks of cancer. Utilising penalised ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s41467-018-07657-1

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
ORCID:
0000-0002-5027-1277
More by this author
Role:
Author
ORCID:
0000-0003-2971-7673
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
ORCID:
0000-0003-0409-406X
More from this funder
Funding agency for:
Dhawan, A
More from this funder
Funding agency for:
Harris, A
More from this funder
Funding agency for:
Buffa, F
Expand funders...
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Publication date:
2018-12-07
Acceptance date:
2018-11-16
DOI:
ISSN:
2041-1723
Source identifiers:
949881
Language:
English
Pubs id:
pubs:949881
UUID:
uuid:34fdafbc-9ba6-4a15-90ee-310cc057d515
Local pid:
pubs:949881
Deposit date:
2018-12-04

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP