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Thesis

Fold recognition and alignment in the ‘twilight zone’

Abstract:

At present, the most accurate approach to predicting protein structure, comparative modelling, builds a model of a target sequence using known protein structures as templates. Comparative modelling becomes markedly less accurate in the ‘twilight zone’, where the target protein shares little sequence identity with all known templates. There are two main causes of this inaccuracy: first, it becomes difficult to identify good structural templates; second, it becomes difficult to determine whi...

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Institution:
University of Oxford
Research group:
Oxford protein informatics group
Oxford college:
Jesus College
Department:
Mathematical,Physical & Life Sciences Division - Other - Life Sciences Interface Doctoral Training Centre
Role:
Author

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Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:353a9832-b2a4-41fb-a9f2-f3cae1a30039
Local pid:
ora:8135

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