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Vitamin B-12 status during pregnancy and child's IQ at age 8: a Mendelian randomization study in the Avon longitudinal study of parents and children

Abstract:

Vitamin B-12 is essential for the development and maintenance of a healthy nervous system. Brain development occurs primarily in utero and early infancy, but the role of maternal vitamin B-12 status during pregnancy on offspring cognitive function is unclear. In this study we assessed the effect of vitamin B-12 status in well-nourished pregnant women on the cognitive ability of their offspring in a UK birth cohort (ALSPAC). We then examined the association of SNPs in maternal genes FUT2 (rs49...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0051084

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Wellcome Trust More from this funder
Wellcome Trust More from this funder
Medical Research Council More from this funder
Wellcome Trust More from this funder
Medical Research Council More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
7
Issue:
12
Pages:
e51084
Publication date:
2012-12-05
Acceptance date:
2012-11-01
DOI:
ISSN:
1932-6203
Pmid:
23227234
Source identifiers:
368242

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