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Astrocytes resist HIV-1 fusion but engulf infected macrophage material

Abstract:

HIV-1 disseminates to diverse tissues and establishes long-lived viral reservoirs. These reservoirs include the central nervous system (CNS) in which macrophage-lineage cells, and, as suggested by many studies, astrocytes may be infected. Here we have investigated astrocyte infection by HIV-1. We confirm that astrocytes trap and internalize HIV-1 particles for subsequent release, but find no evidence that these particles infect the cell. Astrocyte infection was not observed by cell-free or ce...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2017.01.027

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Grant:
MC_UU_12010, G0902418, MC_UU_12025, MR/K01577X/1
Biotechnology and Biological Sciences Research Council More from this funder
Engineering and Physical Sciences Research Council More from this funder
Wolfson Foundation More from this funder
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Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Volume:
18
Issue:
6
Pages:
1473–1483
Publication date:
2017-02-07
Acceptance date:
2017-01-12
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Language:
English
Keywords:
Pubs id:
pubs:672203
UUID:
uuid:354c0d5c-9121-496e-a092-4f573f4a8409
Local pid:
pubs:672203
Deposit date:
2017-01-20

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