Journal article
A novel domain suggests a ciliary function for ASPM, a brain size determining gene
- Abstract:
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The N-terminal domain of abnormal spindle-like microcephaly-associated protein (ASPM) is identified as a member of a novel family of ASH (ASPM, SPD-2, Hydin) domains. These domains are present in proteins associated with cilia, flagella, the centrosome and the Golgi complex, and in Hydin and OCRL whose deficiencies are associated with hydrocephalus and Lowe oculocerebrorenal syndrome, respectively. Genes encoding ASH domains thus represent good candidates for primary ciliary dyskinesias. <...>
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 138.2KB)
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- Publisher copy:
- 10.1093/bioinformatics/btl022
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Authors
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Bioinformatics Journal website
- Volume:
- 22
- Issue:
- 9
- Pages:
- 1031-1035
- Publication date:
- 2006-05-01
- DOI:
- EISSN:
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1460-2059
- ISSN:
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1367-4803
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:359d21be-46a5-4a6d-aa00-dd5405147f51
- Local pid:
- ora:7771
- Deposit date:
- 2014-02-03
Related Items
Terms of use
- Copyright holder:
- Ponting, C
- Copyright date:
- 2006
- Notes:
- Copyright The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org. The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org
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