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Journal article

Macrophages: micromanagers of antagonistic signaling nanoclusters

Abstract:
How cells integrate antagonistic receptor signaling events is enigmatic. Using superresolution optical microscopy, Lopes et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608094) demonstrate the nanometer-scale molecular reorganization of antagonistic signaling receptors in macrophages, after engagement by the receptors of activating and inhibitory ligands. They propose that large-scale rearrangements of this type underpin decision-making by these cells.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1083/jcb.201702028

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Institution:
University of Oxford
Oxford college:
Christ Church
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Medical Research Council More from this funder
Wellcome Trust More from this funder
Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Cell Biology Journal website
Volume:
216
Issue:
4
Pages:
871-873
Publication date:
2017-03-22
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Source identifiers:
687020
Language:
English
Keywords:
Pubs id:
pubs:687020
UUID:
uuid:35c059ad-0763-4ddd-b7b1-a6d5009542c4
Local pid:
pubs:687020
Deposit date:
2017-06-14

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