Journal article
Selective targeting of bromodomains of the bromodomain-PHD fingers family impairs osteoclast differentiation
- Abstract:
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Histone acetyltransferases of the MYST family are recruited to chromatin by BRPF scaffolding proteins. We explored functional consequences and the therapeutic potential of inhibitors targeting acetyl-lysine dependent protein interaction domains (bromodomains) present in BRPF1-3 in bone maintenance. We report three potent and selective inhibitors: one (PFI-4) with high selectivity for the BRPF1B isoform and two pan-BRPF bromodomain inhibitors (OF-1, NI-57). The developed inhibitors displaced B...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 9.5MB)
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- Publisher copy:
- 10.1021/acschembio.7b00481
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Authors
Funding
Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- ACS Chemical Biology Journal website
- Volume:
- 12
- Issue:
- 10
- Pages:
- 2619–2630
- Publication date:
- 2017-08-29
- Acceptance date:
- 2017-08-29
- DOI:
- EISSN:
-
1554-8937
- ISSN:
-
1554-8929
- Pmid:
-
28849908
Item Description
- Language:
- English
- Pubs id:
-
pubs:725804
- UUID:
-
uuid:35cc401b-268d-43a3-b526-a233fa86196b
- Local pid:
- pubs:725804
- Deposit date:
- 2017-09-21
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
- Licence:
- CC Attribution (CC BY)
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