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Computational methods to examine conformational changes and ligand-binding properties: Examples in neurobiology

Abstract:

Many proteins that are central to key aspects of neurobiology undergo conformational changes as part of their function, usually in response to a stimulus. Often, these proteins are embedded within a membrane, which creates particular experimental challenges to surmount. This has resulted in computational methods providing a valuable complementary tool for some time now, especially in the development of working models at atomic resolution. Indeed, molecular dynamics (MD) simulations are now ro...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Lady Margaret Hall
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Neuroscience Letters Journal website
Volume:
700
Pages:
9-16
Publication date:
2018-03-05
Acceptance date:
2018-03-02
DOI:
EISSN:
1872-7972
ISSN:
0304-3940
Pmid:
29518541
Source identifiers:
828749
Language:
English
Keywords:
Pubs id:
pubs:828749
UUID:
uuid:35d6c1c1-d1ef-446f-ab40-ad6cfe4d9561
Local pid:
pubs:828749
Deposit date:
2018-04-18

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