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Journal article

Characterization of subpopulations of chicken mononuclear phagocytes that express TIM4 and CSF1R

Abstract:

The phosphatidylserine receptor, TIM4, encoded by TIMD4, mediates the phagocytic uptake of apoptotic cells. We applied anti-chicken TIM4 monoclonal antibodies, in combination with CSF1R reporter transgenes to dissect the function of TIM4 in chick (Gallus gallus). During development in ovo, TIM4 was present on the large majority of macrophages but expression became more heterogeneous post-hatch. Blood monocytes expressed KUL01, class II MHC and CSF1R-mApple uniformly. Around 50% of monocytes w...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4049/jimmunol.1800504

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0001-9341-2562
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Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
202
Issue:
4
Pages:
1186-1199
Publication date:
2019-02-04
Acceptance date:
2018-12-03
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
920276
Pubs id:
pubs:920276
UUID:
uuid:360091c5-09a6-4985-90af-a127dc43274b
Local pid:
pubs:920276
Deposit date:
2019-03-01

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