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Characterisation of the immunomodulatory effects of meningococcal Opa proteins on human peripheral blood mononuclear cells and CD4+ T cells

Abstract:

Opa proteins are major surface-expressed proteins located in the Neisseria meningitidis outer membrane, and are potential meningococcal vaccine candidates. Although Opa proteins elicit high levels of bactericidal antibodies following immunisation in mice, progress towards human clinical trials has been delayed due to previous findings that Opa inhibits T cell proliferation in some in vitro assays. However, results from previous studies are conflicting, with different Opa preparations and cult...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0154153

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More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
Expand authors...
Meningitis UK More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Publication date:
2016-04-25
Acceptance date:
2016-04-09
DOI:
ISSN:
1932-6203
Source identifiers:
617817
Pubs id:
pubs:617817
UUID:
uuid:3602bda4-4c47-4bda-8a27-2a5ac5075795
Local pid:
pubs:617817
Deposit date:
2016-04-26

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