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Journal article

Combined HDAC and BET inhibition enhances melanoma vaccine immunogenicity and efficacy

Abstract:

The combined inhibition of histone deacetylases (HDAC) and the proteins of the bromodomain and extraterminal (BET) family have recently shown therapeutic efficacy against melanoma, pancreatic ductal adenocarcinoma, testicular, and lymphoma cancers in murine studies. However, in such studies, the role of the immune system in therapeutically controlling these cancers has not been explored. We sought to investigate the effect of the HDAC inhibitor romidepsin (RMD) and the BET inhibitor IBET151, ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4049/jimmunol.1800885

Authors


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Role:
Author
ORCID:
0000-0002-4318-7624
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Role:
Author
ORCID:
0000-0002-9995-1804
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Role:
Author
ORCID:
0000-0002-4498-7893
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0002-9694-2216
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Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
201
Issue:
9
Pages:
2744-2752
Publication date:
2018-10-22
Acceptance date:
2018-08-22
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Pmid:
30249811
Source identifiers:
924218
Language:
English
Keywords:
Pubs id:
pubs:924218
UUID:
uuid:3618713c-a2af-4484-881b-fdabf9f9a3db
Local pid:
pubs:924218
Deposit date:
2019-03-08

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