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Journal article

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Abstract:

We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the genetic architecture of MS that includes 200 autosomal susceptibility variants outside the major histocompatibility complex (MHC), one chromosome X variant, and 32 variants within the extended MHC. We used an ensemble of methods to prioritize 551 putative susceptibility genes that implicate multiple innate and adaptive pathways distributed across the cellular component...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/science.aav7188

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health
Department:
Unknown
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM OCDEM
Role:
Author
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Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Journal website
Volume:
365
Issue:
6460
Article number:
eaav7188
Publication date:
2019-09-27
Acceptance date:
2019-08-06
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Pmid:
31604244
Source identifiers:
1061365
Language:
English
Keywords:
Pubs id:
pubs:1061365
UUID:
uuid:361dc9c3-7e9e-4c78-9f73-b1f86d665ac9
Local pid:
pubs:1061365
Deposit date:
2019-11-19

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