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The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission

Abstract:

Assessing the physical connections and allosteric communications in multi-domain nuclear receptor (NR) polypeptides has remained challenging, with few crystal structures available to show their overall structural organizations. Here we report the quaternary architecture of multi-domain retinoic acid receptor β–retinoic X receptor α (RARβ–RXRα) heterodimer bound to DNA, ligands and coactivator peptides, examined through crystallographic, hydrogen–deuterium exchange mass spectrometry, mutagenes...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-017-00981-y

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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Issue:
2017
Article number:
868
Publication date:
2017-10-11
Acceptance date:
2017-08-09
DOI:
ISSN:
2041-1723
Pmid:
29021580
Source identifiers:
949761
Language:
English
Keywords:
Pubs id:
pubs:949761
UUID:
uuid:361e70ab-519a-43fc-8d91-e8b556cb6ad0
Local pid:
pubs:949761
Deposit date:
2019-08-05

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