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Proton-control of transitions in an amino-acid transporter

Abstract:

Abstract Amino acid transport into the cell is often coupled to the proton electrochemical gradient, as found in the solute carrier (SLC) 36 family of proton coupled amino acid transporters (PATs). Although no structure of a human PAT exists, the crystal structure of a related homolog, GkApcT, from bacteria has recently been solved in an inward occluded state and allows an opportunity to examine how protons are coupled to amino acid transport. Our working hypothesis is that release of the ami...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1101/606913

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More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
ORCID:
0000-0001-7432-2270
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
ORCID:
0000-0001-5100-8836
Publisher:
Biophysical Society Publisher's website
Journal:
Biophysical Journal Journal website
Volume:
117
Issue:
7
Pages:
1342-1351
Publication date:
2019-08-26
Acceptance date:
2019-07-30
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Language:
English
Keywords:
Pubs id:
991075
Local pid:
pubs:991075
Deposit date:
2020-03-19

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