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Understanding principles of integration and segregation using whole-brain computational connectomics: implications for neuropsychiatric disorders

Abstract:

To survive in an ever-changing environment, the brain must seamlessly integrate a rich stream of incoming information into coherent internal representations that can then be used to efficiently plan for action. The brain must, however, balance its ability to integrate information from various sources with a complementary capacity to segregate information into modules which perform specialized computations in local circuits. Importantly, evidence suggests that imbalances in the brain's ability...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1098/rsta.2016.0283

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More from this funder
Funding agency for:
Lord, L
Grant:
Mann Senior Scholarship
More from this funder
Funding agency for:
Lord, L
Grant:
Mann Senior Scholarship
More from this funder
Funding agency for:
Lord, L
Grant:
Mann Senior Scholarship
More from this funder
Funding agency for:
Kringelbach, M
Grant:
CAREGIVING (615539
Publisher:
Royal Society Publisher's website
Journal:
Philosophical Transactions A: Mathematical, Physical and Engineering Sciences Journal website
Volume:
375
Issue:
2096
Article number:
20160283
Publication date:
2017-06-28
Acceptance date:
2016-12-05
DOI:
EISSN:
1471-2962
ISSN:
1364-503X
Source identifiers:
700306
Language:
English
Keywords:
Pubs id:
pubs:700306
UUID:
uuid:36219c3c-aee8-42d8-8448-1add5c49ed6f
Local pid:
pubs:700306
Deposit date:
2017-07-13

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