Journal article
Infection with a Brazilian isolate of Zika virus generates RIG‐I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signalling
- Abstract:
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Zika virus (ZIKV) is a major public health concern in the Americas. We report that ZIKV infection and RNA extracted from ZIKV infected cells potently activated the induction of type I interferons (IFNs). This effect was fully dependent on the mitochondrial antiviral signalling protein (MAVS), implicating RIG‐I‐like receptors (RLRs) as upstream sensors of viral RNA. Indeed, RIG‐I and the related RNA sensor MDA5 contributed to type I IFN induction in response to RNA from infected cells. We foun...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 3.2MB)
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- Publisher copy:
- 10.1002/eji.201847483
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Authors
Funding
+ European Commission
More from this funder
Funding agency for:
Hertzog, J
Grant:
H2020 MSCA-ITN GA 675278 EDGE
+ Conselho Nacional de Desenvolvimento Científico e Tecnológico
More from this funder
Funding agency for:
Dias, A
Grant:
211806/2013-7
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- European Journal of Immunology Journal website
- Volume:
- 48
- Issue:
- 7
- Pages:
- 1120-1136
- Publication date:
- 2018-03-23
- Acceptance date:
- 2018-03-12
- DOI:
- EISSN:
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1521-4141
- ISSN:
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0014-2980
Item Description
- Keywords:
- Pubs id:
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pubs:831758
- UUID:
-
uuid:3631e2f2-558d-4f95-9bf1-5b3d437fc615
- Local pid:
- pubs:831758
- Deposit date:
- 2018-03-26
Terms of use
- Copyright holder:
- Hertzog, etal
- Copyright date:
- 2018
- Notes:
- © 2018 The Authors. European Journal of Immunology published by WILEY‐VCH Verlag GmbH and Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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