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The evolutionary landscape of alternative splicing in vertebrate species.

Abstract:

How species with similar repertoires of protein-coding genes differ so markedly at the phenotypic level is poorly understood. By comparing organ transcriptomes from vertebrate species spanning ~350 million years of evolution, we observed significant differences in alternative splicing complexity between vertebrate lineages, with the highest complexity in primates. Within 6 million years, the splicing profiles of physiologically equivalent organs diverged such that they are more strongly relat...

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Publisher copy:
10.1126/science.1230612

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Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
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Journal:
Science (New York, N.Y.)
Volume:
338
Issue:
6114
Pages:
1587-1593
Publication date:
2012-12-01
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Source identifiers:
433113

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