Journal article
Synthesis of 1,3-disubstituted bicyclo[1.1.0]butanes via directed bridgehead functionalization
- Abstract:
-
Bicyclo[1.1.0]butanes (BCBs) are increasingly valued as intermediates in ‘strain release’ chemistry for the synthesis of substituted four membered rings and bicyclo[1.1.1]pentanes, with applications including bioconjugation processes. Variation of the BCB bridgehead substituents can be challenging due to the inherent strain of the bicyclic scaffold, often necessitating linear syntheses of specific BCB targets. Here we report the first palladium catalyzed cross-coupling on pre-formed BCBs whic...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Funding
Bibliographic Details
- Publisher:
- Royal Society of Chemistry Publisher's website
- Journal:
- Chemical Science Journal website
- Volume:
- 12
- Issue:
- 21
- Pages:
- 7480-7485
- Publication date:
- 2021-04-27
- Acceptance date:
- 2021-04-26
- DOI:
- EISSN:
-
2041-6539
- ISSN:
-
2041-6520
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1177181
- Local pid:
- pubs:1177181
- Deposit date:
- 2021-06-22
Terms of use
- Copyright holder:
- McNamee et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 The Author(s). Published by the Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
- Licence:
- CC Attribution (CC BY)
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