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Journal article

SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis.

Abstract:

OBJECTIVE: Single-immunoglobulin interleukin-1 receptor-related (SIGIRR), which is also known as Toll/interleukin-1 receptor 8 (TIR-8), is a member of the TIR domain-containing family of receptors and was first characterized as an inhibitor of interleukin-1 receptor (IL-1R) and Toll-like receptor (TLR) signaling. In the Dextran sulfate sodium-induced colitis model, SIGIRR(-/-) mice were shown to have increased inflammation and to be more susceptible to endotoxin challenge. Increasing evidenc...

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Publication status:
Published

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Publisher copy:
10.1002/art.27517

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Journal:
Arthritis and rheumatism
Volume:
62
Issue:
8
Pages:
2249-2261
Publication date:
2010-08-01
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
Source identifiers:
224958

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