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Journal article

Nested Russian doll-like genetic mobility drives rapid dissemination of the carbapenem resistance gene blaKPC

Abstract:

The recent widespread emergence of carbapenem resistance in Enterobacteriaceae is a major public health concern, as carbapenems are a therapy of last resort in this family of common bacterial pathogens. Resistance genes can mobilize via various mechanisms including conjugation and transposition, however the importance of this mobility in short-term evolution, such as within nosocomial outbreaks, is currently unknown. Using a combination of short- and long-read whole genome sequencing of 281 b...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/AAC.00464-16

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Funding agency for:
Stoesser, N
Grant:
Research Fellowship
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Funding agency for:
Wilson, D
Grant:
Sir Henry Dale Fellowship 101237/Z/13/Z
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Funding agency for:
Wilson, D
Grant:
Sir Henry Dale Fellowship 101237/Z/13/Z
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Grant:
Health Innovation Challenge Fund HICF-T5-358
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Grant:
Health Innovation Challenge Fund WT098615/Z/12/Z
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Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Publication date:
2016-05-23
Acceptance date:
2016-04-03
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Source identifiers:
613088
Pubs id:
pubs:613088
UUID:
uuid:3651d24e-6612-4948-b975-437c440b1787
Local pid:
pubs:613088
Deposit date:
2016-04-04

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