Thesis
Metabolic adaptations to micro-environmental stress in tumour spheroids
- Abstract:
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Alterations in energy metabolism due to factors including cellular stress from the hostile tumour micro-environment are a emerging cancer hallmark. Distinct hypoxic and quiescent cell populations develop, which are resistant to chemotherapy due to lack of proliferation, drug inactivity in the altered redox status of the cell and enhanced drug biotransformation. The present study characterises the metabolic strategies employed by these distinct populations of cancer cells. The in vitro<...>
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Authors
Contributors
+ Callaghan, R
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Supervisor
+ Board, M
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Supervisor
+ Boultwood, J
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:3651d265-ddc0-4258-b3f7-2a0242697d21
- Local pid:
- ora:11419
- Deposit date:
- 2015-05-11
Terms of use
- Copyright holder:
- Smith, H
- Copyright date:
- 2014
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