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Thesis

Metabolic adaptations to micro-environmental stress in tumour spheroids

Abstract:

Alterations in energy metabolism due to factors including cellular stress from the hostile tumour micro-environment are a emerging cancer hallmark. Distinct hypoxic and quiescent cell populations develop, which are resistant to chemotherapy due to lack of proliferation, drug inactivity in the altered redox status of the cell and enhanced drug biotransformation. The present study characterises the metabolic strategies employed by these distinct populations of cancer cells. The in vitro<...>

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Oxford college:
Green Templeton College
Role:
Author

Contributors

Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Supervisor
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Supervisor
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:3651d265-ddc0-4258-b3f7-2a0242697d21
Local pid:
ora:11419
Deposit date:
2015-05-11

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