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[Mutation of the FGFR3 oncogene is an independent and favorable prognostic factor for tumor-specific survival in patients with urothelial carcinoma of the upper urinary tract].

Abstract:

AIMS: Urothelial tumors of the upper urinary tract (UUTT) frequently display microsatellite Instability (MSI) and a distinct pathway of tumorigenesis resembling MMR-deficient colorectal cancers has been recognized for MSI-UUTT. For MSS-UUTT however oncogenic mechanisms as in bladder cancer (BC) are debated. Mutation of the oncogene FGFR3 has been linked to lower stage, lower grade and favourable clinical outcome in BC. The aim of this study was to evaluate FGFR3 mutation in MSI and MSS-UUTT....

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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
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Journal:
Verhandlungen der Deutschen Gesellschaft fur Pathologie
Volume:
90
Pages:
244-252
Publication date:
2006-01-01
ISSN:
0070-4113
Source identifiers:
120635
Language:
German
Keywords:
Pubs id:
pubs:120635
UUID:
uuid:36630059-f996-4ca0-93de-16e9a52cd8b1
Local pid:
pubs:120635
Deposit date:
2013-02-20

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