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RNA-free and ribonucleoprotein-associated influenza virus polymerases directly bind the serine-5 phosphorylated carboxyl-terminal domain of host RNA polymerase II

Abstract:

Influenza viruses subvert the transcriptional machinery of their hosts to synthesise their own viral mRNA. Ongoing transcription by cellular RNA polymerase II (Pol II) is required for viral mRNA synthesis. By a process known as cap-snatching, the virus steals short 5ʹ capped RNA fragments from host capped RNAs and uses these to prime viral transcription. An interaction between the influenza A virus RNA polymerase and the C-terminal domain (CTD) of the large subunit of Pol II has been establis...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/JVI.00494-16

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More from this funder
Funding agency for:
Fodor, E
Grant:
MR/K000241/1
More from this funder
Funding agency for:
Hengrung, N
Grant:
Studentship 092931/Z/10/Z
More from this funder
Funding agency for:
Martinez-Alonso, M
Grant:
FP7/2007-2013) Marie Curie Intra European Fellowship
Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of Virology Journal website
Publication date:
2016-04-20
Acceptance date:
2016-04-13
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Source identifiers:
616079
Pubs id:
pubs:616079
UUID:
uuid:366ad87c-1765-4616-812c-0725718ffd9a
Local pid:
pubs:616079
Deposit date:
2016-04-15

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