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Journal article

RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.

Abstract:

Transition from pluripotency to differentiation is a pivotal yet poorly understood developmental step. Here, we show that the tumour suppressor RASSF1A is a key player driving the early specification of cell fate. RASSF1A acts as a natural barrier to stem cell self-renewal and iPS cell generation, by switching YAP from an integral component in the β-catenin-TCF pluripotency network to a key factor that promotes differentiation. We demonstrate that epigenetic regulation of the Rassf1A promoter...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-017-02786-5

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
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Medical Research Council More from this funder
Science Foundation Ireland More from this funder
Russian Federal Agency for Scientific Organizations More from this funder
Pancreatic Cancer UK More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Pages:
424
Publication date:
2018-01-01
Acceptance date:
2017-12-29
DOI:
EISSN:
2041-1723
Pmid:
29382819
Source identifiers:
822770
Language:
English
Keywords:
Pubs id:
pubs:822770
UUID:
uuid:366de650-c0fc-40a2-959c-562a2e1acb94
Local pid:
pubs:822770
Deposit date:
2018-02-06

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