Journal article
RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.
- Abstract:
-
Transition from pluripotency to differentiation is a pivotal yet poorly understood developmental step. Here, we show that the tumour suppressor RASSF1A is a key player driving the early specification of cell fate. RASSF1A acts as a natural barrier to stem cell self-renewal and iPS cell generation, by switching YAP from an integral component in the β-catenin-TCF pluripotency network to a key factor that promotes differentiation. We demonstrate that epigenetic regulation of the Rassf1A promoter...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Wellcome Trust
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Pancreatic Cancer UK
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Russian Federal Agency for Scientific Organizations
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Science Foundation Ireland
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 9
- Issue:
- 1
- Pages:
- 424
- Publication date:
- 2018-01-01
- Acceptance date:
- 2017-12-29
- DOI:
- EISSN:
-
2041-1723
- Pmid:
-
29382819
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:822770
- UUID:
-
uuid:366de650-c0fc-40a2-959c-562a2e1acb94
- Local pid:
- pubs:822770
- Source identifiers:
-
822770
- Deposit date:
- 2018-02-06
Terms of use
- Copyright holder:
- Lu et al
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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