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Detection of a SARS-CoV-2 variant of concern in South Africa

Abstract:

Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus1,2. Here we describe a newly arisen lineage of SARS-CoV-2 (designated 501Y.V2; also known as B.1.351 or 20H) that is defined by eight mutations in the spike protein, including three substitutions (K417N, E484K and N501Y) at residues in its receptor-binding domain that may have functional importance3,4,5. This lineage was identified in South Afri...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41586-021-03402-9

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Role:
Author
ORCID:
0000-0002-5849-7326
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Role:
Author
ORCID:
0000-0001-5521-6448
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Journal website
Volume:
592
Issue:
7854
Pages:
438-443
Publication date:
2021-03-09
Acceptance date:
2021-02-26
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pmid:
33690265

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