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Journal article

A statistical interaction between circumsporozoite protein-specific T cell and antibody responses and risk of clinical malaria episodes following vaccination with RTS,S/AS01E

Abstract:

The candidate malaria vaccine RTS,S/AS01E provides significant but partial protection from clinical malaria. On in vitro circumsporozoite protein (CSP) peptide stimulation and intra-cellular cytokine staining of whole blood taken from 407 5–17 month-old children in a phase IIb trial of RTS,S/AS01E, we identified significantly increased frequencies of two CSP-specific CD4+ T cells phenotypes among RTS,S/AS01E vaccinees (IFNγ-IL2+TNF− and IFNγ-IL2+TNF+ CD4+ T cells), and increased frequency of ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0052870

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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
7
Issue:
12
Pages:
ARTN e52870
Publication date:
2012-12-27
Acceptance date:
2012-11-21
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
371578
Language:
English
Keywords:
UUID:
uuid:367466d5-51e9-48a7-b00c-d3a9513de6ff
Local pid:
pubs:371578
Deposit date:
2013-11-16

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